261 patients with advanced breast carcinoma were xate combined with an alkylati:~g agent in sequence,
treated with a special sequential therapeutic regimen. The results show that there is significant increase of 1,
This sequential regimen, consists of oophorectomy for all 2, 3, 4, and 5 year survival time in responders of
premenopausal woman and adrenalectomy for most of hormonal therapies who are subsequently treated with
postmenoausal woman and ´ for selected premenopausal sequential chemotherapy in contrast to those who are
woman having had response to previous oophorectomy. hormonal non-responders,
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